The Study of Nimodipine in Treating Pregnancy Induced Hypertension and its Effect on Intraplatelet Free Calcium
- VernacularTitle:尼莫地平治疗妊娠高血压综合征及其对血小板细胞内游离钙离子浓度影响的研究
- Author:
Huiru WANG
;
Wenli GOU
;
Xuelan LI
- Publication Type:Journal Article
- Keywords:
Pregnancy complications, cardiovascular;
Hypertension;
Nimodipine;
Magnesium sulfate;
Blood platelets;
Calcium
- From:
Chinese Journal of Perinatal Medicine
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of nimodipine (NIM) on pregnancy induced hypertension(PIH) and to assesse the effects of nimodipine on intraplatelet free calcium(PF[Ca 2+ ] i). Methods Fourty eight patients with moderate or severe PIH were randomized to receive either NIM or magnesium sulfate. We observed the change of blood pressure, urc protein, PF[Ca 2+ ] i and symptoms of preeclampsia before and after medication. We compared the pregnancy outcome of the two groups. Results 1.There was significant reduction of blood pressure at 1/2 h?1 h and 2 h after the administration of nimodipine. The maternal heart rate increased significantly ( P
