Relationship Between the Expression of c-fos Gene and Delayed Neuronal Death in the Neonatal Hippocampus Following Hypoxia-ischamia Insult
- VernacularTitle:缺氧缺血后新生鼠脑c-fos表达与脑海马迟发性神经元死亡
- Author:
Li JIANG
;
Yanjie DING
;
Guangrong JIN
- Publication Type:Journal Article
- Keywords:
Cerebral anoxia;
Cerebral ischemia;
Genes, fos;
Apoptosis
- From:
Chinese Journal of Perinatal Medicine
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the expression of c fos gene and delayed neuron death in perinatal hypoxia ischamia encephalopathy (HIE). Methods Terminal deo xynuleotidyl transferase mediated dUTP nick end labeling (TUNEL), immuno histochemistry andreverse transcription PCR(RT PCR) were used to detect the apoptosis and transcription and translation of c fos gene in the hippocampus following HIE. Results Positive signal of apoptosis from CA1 to CA4 sections were observed in experimental hippocampi. Marked signal appeared earlier and longer in CA1 section than in the other sections[CA1: 1 h: (14.6?2.3),24 h: (51?6),72 h: (17.4?0.3);CA4:1 h :1.3?1.6),24 h: (47?8),72 h: (21.6?0.6) apoptosis cell number/ mm 2 ],compared with the sham group of CA1 section P
