Variation of Leptin Receptor Gene and Their Relation to Lipid Metabolism,Insulin Sensitivity Index and High Blood Coagulation State in Type 2 Diabetes
- VernacularTitle:瘦素受体基因变异与2型糖尿病脂代谢紊乱、胰岛素抵抗及血高凝状态的关系研究
- Author:
Hongyun LU
;
Yancheng XU
;
Yilian ZHU
- Publication Type:Journal Article
- Keywords:
Leptin receptor;
Type2 diabetes mellitus;
Lipid metabolism;
Insulin resistance;
High blood coagulation
- From:
Journal of Chinese Physician
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship among the leptin receptor(lepr) gene exon 20,nucleotide 3057 G→A transition and lipid metabolism,insulin sensitivity index,high blood coagulation in type2 diabetes mellitus.Methods Polymerase chain reaction(PCR) and restriction fragment length polymorphism(RFLP) were used to detect the variation of leptin receptor gene nucleotide 3057 G→A transition;Simultaneusly,we detected some parameters,including blood lipids,height,weight,blood glucose,waistline to hipline ratio(WHR).The body mass index(BMI),fat percent,insulin sensitivity index(ISI) were calculated out in all subjects.Results The variation frequency at 3057 nucleotide G→A transiton was 80% in type 2 diabetic group,though it was 68% in control group(P
