Significance of the expressions of VEGF mRNA, bFGF mRNA,PDGF mRNA and their receptors in pancreatic carcinoma
- VernacularTitle:胰腺癌中VEGF mRNA,bFGF mRNA和PDGF mRNA及相应受体的表达与意义
- Author:
Henggui LUO
;
Zhulin YANG
;
Yingwen DING
;
Mingliang GAO
;
Tiexiang MA
;
Li WANG
;
Yonggu LI
- Publication Type:Journal Article
- Keywords:
PANOREATIC NEOPLASMS/genet;
ENDOTHELIAL GROWTH FACTORS;
FIBROBLAST GROWFH FACTORS, BASTC;
PLATELET-DERIVED GROWTH FACTORS;
GENE EXPRESSIONS;
PANCREATIC NEOPLASMS/pathol
- From:
Chinese Journal of General Surgery
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of intratumor angiogenesis and vascular growth factor(VEGF), basic fibroblase growth factor(bFGF), Platelet-derived growth factor (PDGF), and their receptors(flt-1 bFGFR.PDGFR) on the invasion, metaslasis of pancreatic carcimoma(PC) and the relationship between the expressions of three kinds of angiogenic factors, their receptors and microvessel count(MVC). Methods Tis- sue sections of 51 PC and 32 acute or chronic pancreatitis were examined by in situ hybridization for the expression of VEGF bFGF.PDGF, and by immunohistochemistry for the expression of the three kinds of angiogenic factor receptors and MVC. The correlation of the expressions and pathological characteristics of PC were also studied. Results The positive rate of VEGF mRNA,bFGF mRNA, PDGF mRNA and their receptors in PC were significantly higher than that in acute or chronic pancreatistis( P
