Lipid peroxidation injures in hemorrhagic shock at high altitude by oxygenate solution resuscitation in rabbits
- VernacularTitle:氧合液复苏减轻高原出血性休克脂质过氧化损伤的实验研究
- Author:
Qiquan ZHOU
;
Heping WU
;
Shi ZHANG
;
Ya LAI
- Publication Type:Journal Article
- Keywords:
SHOCK, HEMORRHAGIC/prev;
ALTITUDE;
LIPID PEROXIDATION/drug eff;
OXYGENATA SOLUTION/ther use;
OXYGENATA SOLUTION/pharm
- From:
Chinese Journal of General Surgery
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the antishock effect of oxygenate solution and its possible mechanism. Methods The protective effects of oxygenates hypertonic hypercolloid solution on lipid peroxidation injures in hemorrhagic shock in rabbits at 4 700 m high altitude spot was observed. Results The oxygenated solution treatment can obviously reduce the malondialdehyde(MDA) and glutathione(GSH) level in plasma and tissue ; and increase the superoxide diamutase(SOD) and glutathione peroxidase(GSH-PX) level in plasma and tissue of the hemorrhagic shock animals. Conclusions Oxygenatea solution treatment can reduce the lipid peroxidation injure, recover the equilibrium of oxidation and antioxidation with shock body in time, and promote the resuscitation of shock.
