Changes in monoamine oxidase activity during thrombotic cerebral ischemia and protection mechanisms of ginkgolide B in tree shrews
- VernacularTitle:树鼩血栓性脑缺血时单胺氧化酶活性的变化及银杏内酯B作用机制探讨
- Author:
Jiali LI
;
Shuqing LI
- Publication Type:Journal Article
- Keywords:
Photochemistry;
Cerebral Ischemia;
Monoamine oxidase;
Neuroregulators;
Tupaiidae
- From:
Chinese Journal of Pathophysiology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: The present study was designed to examine changes in monoamine oxidase (MAO) activity during cerebral ischemia and whether ginkgolide B's brain protection challenges with inhibiting monoamine oxidase. METHODS: The focal thrombotic cerebral ischemia was formed by photochemistry-induced in tree shews .MAO activities in different areas which include ischemic,core, penumbra and contralater and serum, were tested by enzyme color-compared way. The protein contents in different area above was examined by amino acid autoanalytic apparatus. RESULTS: MAO activities in ischemic core in different group were much lower than that in the sham operation group [(15.41?1.63)?10 3 U/g protein] and contralatetral areas [(15.47?1.66)?10 3 U/g protein], with its peak at seventy-two hours after occlusion, but that in penumbra [(25.37?2.01)?10 3 U/g protein] and serum [(210.04?20.67)?10 3U/L] ascended. There were significant differences in MAO activities between ischemic group and control (P
