Muscarinic receptor subtypes and gastrointestinal smooth muscle function
- VernacularTitle:M受体亚型和胃肠道平滑肌功能
- Author:
Bin WANG
;
Fengtao CHENG
- Publication Type:Journal Article
- Keywords:
Muscarine;
Muscle, smooth;
Gastrointestinal system
- From:
Chinese Journal of Pathophysiology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
The muscarinic receptor family expressed in smooth muscle throughout the body is thought to be composed of five subtypes coupling to distinct signaling systems,respectively.The population in smooth muscle is composed of mainly M 2 and M 3 subtypes in a 80% to 20% mixture. The muscarinic receptor, mainly M 3 receptor, play an important role in regulating gastrointestinal smooth muscle contraction. Selective muscarinic M 3 antagonist should have therapeutic utility in the treatment of gastrointestinal disease.
