Effects of somatostatin on ?-glycuronidase (?-G) activity in blood and perit oneal exudate in a simian model of acute necrotic pancreatitis
- VernacularTitle:急性坏死性胰腺炎猴?葡萄糖醛酸酶活性的变化及生长抑素对其的作用
- Author:
Zhiying YANG
;
Weisong TANG
;
Ping ZHAO
- Publication Type:Journal Article
- Keywords:
Pancreatitis, acute necrotizing;
Somatostatin;
Glycuronidase
- From:
Chinese Journal of General Surgery
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe changes of ?-glycuronida se (?-G) activity in blood and intraabdominal exudate in a monkey model with ac ute necrotic pancreatitis and the effects of somatostatin.Method The ANP model was induced by intrapancreatic duct injection of bile and 5% trypsin. Somatostatin was administrated at a dosage of 10 ?g?kg~-1?h~-1 in the treatment group (6 monkeys), w hile normal saline was given in 6 control monkeys. Blood and exudate were col lected for the meas urement of ?-G activity (?g/h?ml~-1). Resul ts (1)the mortality rate was 100% and 50% in the control group and treatment group, and the average survival time was (31?9) h and (53 ?24) h (P
