The effect of NO precursor or NOS inhibitor on survival of rats with acute liver failure
- VernacularTitle:一氧化氮对急性肝功能衰竭大鼠生存的影响
- Author:
Yangde ZHANG
;
Jianmin QIN
;
Jian PENG
- Publication Type:Journal Article
- Keywords:
Liver failure,acute;
Nitric oxide;
Nitric-oxide synthase
- From:
Chinese Journal of General Surgery
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the e ff ect of NO precursor or/and NOS inhibitor on the survival of acute liver failure( ALF) rats.MethodsModel of ALF rat was established by resecting 90% of the rat liver and the effect of NO prec ursor or/and NOS inhibitor was observed.Resu ltsAdministration of NO precursor significantly improved the liver, lung, kidney and bowel function. The rats′ survival rate at 24 h, and 72 h increased significantly, whereas NOS inhibitor deteriorated fu nctions of important organs(P
