Study on the Action of Norfloxacin Zinc Against Experimental Gastric Ulcer in Rats
- VernacularTitle:诺氟沙星锌抗大鼠实验性胃溃疡作用研究
- Author:
Shenghao WANG
;
Xinyue ZHANG
;
Gaoli ZHENG
;
Fang LIN
;
Jue CHEN
- Publication Type:Journal Article
- Keywords:
norfloxacin zinc;
gastric ulcer;
Hp
- From:
China Pharmacy
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the antiulcer action of norfloxacin zinc(NF-Zn) METHODS:Acute and chronic gastric ulcer models were established in rats and the in vitro action of neutralizing hydrochloric acid and the MIC for Hp of NF-Zn were determined RESULTS:NF-Zn could inhibit the formation of acute gastric ulcer induced by ethanol,stress and salicylic acid in rats,accelerate the healing of chronic gastric ulcer produced by acetic acid,inhibit the secretion of gastric acid and increase the pH in gastric juice In vitro,NF-Zn could neutralize HCl and inhibit Hp with MIC50 of 0 5?g/ml CONCLUSION:The results suggest that the antiulcer action of NF-Zn may be related with its protection of the gastric mucosal barrier,neutralization of acid and inhibition of Hp
