Study on the Influence of Arsenic Trioxide on the Expressions of Gastric Cancer Cell Metastasis Associated Genes
- VernacularTitle:三氧化二砷对人胃癌细胞转移相关基因表达的影响
- Author:
Tao LIANG
;
Tiefu LIU
;
Zhanjun MA
;
Lijun SHI
;
Yinhua TANG
- Publication Type:Journal Article
- Keywords:
arsenic trioxide(As2 O 3 );
human gastric carcinoma cell;
gene expression
- From:
China Pharmacy
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To detect the expressions of five gastric cancer cell metastasis associated genes induced by arsenic trioxide METHODS:The expressions of CD44,P53,nm23,H-ras,PCNA induced by arsenic trioxide were examined by immunohistochemistry method RESULTS:Arsenic trioxide induced the decrease of the expressions of CD44,P53,PCNA in gastric cancer cells;the expressions of nm23 and H-ras were not changed by As2 O 3 CONCLUSION:It is tentatively proved that the antineoplastic action of As2 O 3 may be related to the down-regulation of CD44,P53 and PCNA
