Application of a New Vierordt Method to the Assay of Ingredients in Two Compound Fleroxacin Preparations
- VernacularTitle:联立方程组新解法在含氟罗沙星复方制剂分析中的应用
- Author:
Zhiqiang REN
;
Hong JIANG
;
Aibing LONG
;
Xianwei LI
;
Kewu XIAO
- Publication Type:Journal Article
- Keywords:
compound fleroxacin suppository;
compound fleroxacin ear drops;
determination of content;
New Vierordt method
- From:
China Pharmacy
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish a New Vierordt method for assaying ingredients in compound fleroxacin suppositories and compound fleroxacin ear drops METHODS:New Vierordt method was applied to determination of fleroxacin and tinidazole in compound fleroxacin suppositories and fleroxacin and metronidazole in compound fleroxacin ear drops with no need of separation RESULTS:The fleroxacin and tinidazole in compound fleroxacin suppositories were detected at wavelength 286nm and 317nm respectively The average recoveries were 100 17% and 99 96% with RSDs=0 44% and 0 37% respectively The fleroxacin and metronidazole in the compound fleroxacin ear drops were detected at wavelength 286nm and 318nm respectively The average recoueries were 100 65% and 99 92% with RSDs=0 65% and 0 21% respectively CONCLUSION:The New Vierordt method can be used for quality control of the two compound preparations because of its convenience,accuracy and good repeatability and can eliminate mutual interference of two ingredients in preparations
