Effect of basic fibroblast growth factor on synthesis of C-type natriuretic peptide in cultured human umbilical vein endothelial cells
- VernacularTitle:碱性成纤维细胞生长因子对人脐静脉内皮细胞合成C-型利钠利尿肽的影响
- Author:
Xiaohong WANG
;
Yongfen QI
;
Yonggang ZHANG
;
Sanbao CHAI
;
Yongzheng PANG
;
Chaoshu TANG
- Publication Type:Journal Article
- Keywords:
Natriuretic peptide, C-type;
Fibroblast growth factor, basic;
Endothelium;
Cells
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of basic fibroblast growth factor (bFGF) on C-type natriuretic peptide (CNP) production, release and mRNA expression. METHODS: Human endothelial cell cultured; CNP was measured by radioimmunoassay method;CNP mRNA expression was determined by RT-PCR technique. RESULTS: bFGF could augment CNP synthesis in human endothelial cells. Compared with control group,25 ng, 50 ng, 100 ng bFGF increased CNP contents in endothelial cells by 88% (P
