XBP-01 accelerated apoptosis induced by oxidized low density lipoprotein in vascular smooth muscle cells
- VernacularTitle:消斑肽加速氧化低密度脂蛋白诱导的血管平滑肌细胞凋亡
- Author:
Zhonghua YUAN
;
Yongzong YANG
;
Xiaoyi YANG
;
Jianmiao TAN
;
Zaiyang WAN
- Publication Type:Journal Article
- Keywords:
Peptides;
Lipoproteins, LDL;
Muscle, smooth, vascular;
Cells;
Apoptosis
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: Previous studies performed with XBP-01 in vitro indicated that XBP-01 could inhibit vascular smooth muscle cells from being transformed into foam cell and could eliminate the atherosclerotic plaque in C57 BL/6J mouse. This experiment is to investigate its mechanism of eliminating plaques in vitro. METHODS: The cultured porcine artery smooth muscle cells incubated with XBP-01 of 0.1 mg/L for 24 hours after preincubated with oxidized low density lipoprotein of 15 mg/L for 72 hours in vitro. The samples were analyzed by fluorescence microscope?confocal microscope system and flow cytometry. RESULTS: Apoptosis was triggered by being incubated with oxidized low density lipoprotein and this process was accelerated additionally by being incubated with XBP-01. CONCLUSION: XBP-01 can be effective in eliminating atherosclerotic plaque by accelerating the process in which oxidized low density lipoprotein induced smooth muscle cell apoptosis
