Effects of dietary sodium on the expression of angiotensinogen mRNA in myocardium of rats with congestive heart failure
- VernacularTitle:限钠或补钠对充血性心衰大鼠心肌血管紧张素原mRNA表达的影响
- Author:
Suzhen ZHANG
;
Yong XU
;
Yu WAN
;
Gang YANG
;
Zhijiao TANG
;
Jianmi HU
- Publication Type:Journal Article
- Keywords:
Heart failure, congestive;
Renin-angiotensin system;
Angiotensinogen;
Sodium;
Hybridization
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: This study was designed to investigate the effects of sodium restriction and sodium supplementation on the expression of angiotensinogen mRNA in myocardium of rats with congestive heart failure(CHF).METHODS: Radioimmunassay and in situ hybridization techniques were used to determine the angiotensin Ⅱ(AngⅡ)contents and the expression of angiotensinogen(ANG)mRNA in myocardium, respectively.RESULTS: In sodium restricted group, the plasma sodium was obviously lower than that in CHF group(P
