Alteration of serum interleukin-6 and tumor necrosis factor-? after ischemic stimulation of coronary artery in PTCA
- VernacularTitle:冠脉成形术缺血性刺激前后血清IL-6、TNF-?水平的变化
- Author:
Fang LI
;
Xianming KONG
;
Guanggong WANG
;
Jilin CHEN
;
Jifu LI
;
Yuguo CHEN
;
Guishuang LI
;
Tongtao LIU
;
Qixin PAN
- Publication Type:Journal Article
- Keywords:
Myocardial ischemia;
Reperfusion;
Interleukin-6;
Tumor necrosis factor
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: Inflammatory responses play an important role in the post- percutaneous transluminal coronary angioplasty (PTCA) restenosis and has been demonstrated occuring immediately after PTCA. Interleukin-6(IL-6) and tumor necrosis factor-?(TNF-?) are the main inflammatory cytokines. We try to compare the changes in interleukin-6(IL-6) and TNF-? after PTCA in the patients with and without collateral circulation to probe into the pathogenesis of early inflammatory response. METHODS: The extent of myocardial ischemia induced by balloon inflation was quantified by a scoring system referring to the Leaman coronary score. The IL-6?TNF-? levels of coronary heart disease group and control group before and after PTCA are calculated. RESULTS: The concentrations of IL-6 and TNF-? were (9.592?1.847) ng/L and (26.959?1.967) ng/L, respectively, and were significantly increased [(27.423?1.882) ng/L and (78.542?1.573) ng/L)] 4 hours after PTCA. CONCLUSION: IL-6 and TNF-? are sensitive indicators of the early inflammatory response after PTCA. Ischemia scores reflected the extent of ischemia reperfusion injury during PTCA. Collateral circulation decreased the early inflammatory response after PTCA.
