Changes in action potential and the conduction time of ventricular cells in subendocardium and subepicardium during ischemia and early reperfusion
- VernacularTitle:心肌缺血和再灌注早期心内、外膜下心室肌细胞动作电位时程和传导变化
- Author:
Shuqin LIU
;
Bingxiang YUAN
;
Zengli LI
;
Min JU
;
Baopin LI
- Publication Type:Journal Article
- Keywords:
Myocardial reperfusion injury;
Endocardium;
Action potentials
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the electrophysiological characteristics of ventricular myocyte both in subendocardium and in subepicardium during ischemia. METHODS: Using modified Ferrier's method of ischemic and reperfusion injury in isolated guinea pig right ventricular wall. RESULTS: The transmembranal electric activities in subendocardium and in subepicardium were all significantly abnormal, and it was more significant in subendocardium. CONCLUSION: The alteration degree of ventricular myocyte in subendocardium and in subepicardium during ischemia and early reperfusion was different, and this might be the electrophysiological basis of the vulnerability of the subendocardium.
