Role of stress in the lung injury caused by acute hemorrhagic necrotizing pancreatitis in rats
- VernacularTitle:应激在急性出血坏死性胰腺炎所致肺损伤中的作用
- Author:
Rui XU
;
Zhongli AI
;
Zhisu LIU
;
Quan SUN
;
Yanguo YAN
;
Guoying HE
- Publication Type:Journal Article
- Keywords:
Stress;
Lung;
Pancreatitis
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the relation ship between stress and lung injury caused by acute hemorrhagic necrotizing pancreatitis(AHNP) through AHNP model.METHODS: The AHNP model was made by using 5% sodium taurocholate retrograded injection into biliopancreatic duct in SD rats. Those rats were divided into three groups randomly, from A to C, the A group undertook sham operations, the B group was made into AHNP model, and the C group was given Metyrapone. The level of corticosteroid, CRP and amylase in serum had been observed. The lung and pancreas histological examinations were also performed.RESULTS: In C group, the level of corticosteroid, CRP and amylase were much lower than those in B group. The grade of lung and pancreas injury were also lower than those in B group(P
