Somatostatin expression in rat islet of steroid diabetes mellitus
- VernacularTitle:生长抑素在类固醇糖尿病大鼠胰腺中的表达
- Author:
Fanglin ZHANG
;
Chuanzhong YE
;
Kaizhe ZHANG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Dexamethasone;
Insulin;
Somatostatin
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effects of dexamethasone(DEX) on the pancreatic endocrine function when steroid diabetes mellitus(SDM) occurred. METHODS: 140 rats were randomly assigned to 4 groups according to the clinic doses of DEX administration, Radioimmunoassay and in situ hybridization were applied to evaluate islet hormone changes in pancreas and blood.RESULTS: Changes in fasting blood glucose(FBG) ?fasting serum insulin(FINS) caused by DEX were dose and time-dependent. Changes in somatostatin(SS)mRNA and protein in islet as well as FINS occurred earlier than that of FBG. CONCLUSION: The super-physiological DEX influenced the expression SS and insulin secretion in islet, which may play an important role in SDM.
