Effects of progesterone on water, sodium, potassium and calcium contents in striatum of rats with focal cerebral ischemia/reperfusion
- VernacularTitle:孕酮对脑缺血再灌注大鼠纹状体水、钠、钾及钙含量的影响
- Author:
Dongliang LI
;
Honggang ZHAO
;
Dongxia WANG
;
Yingjie QI
;
Sufeng ZHOU
;
Jingzhuan XI
;
Xiume BAO
- Publication Type:Journal Article
- Keywords:
Progesterone;
Cerebral ischemia;
Sodium;
Potassium;
Calcium
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the neuroprotective action of progesterone(PROG), which has been proved to be a "neuroactive steroid". METHODS: The model of focal cerebral ischemia was established in rats by reverserble inserting a nylon thread with a diameter of 0.2 mm into the anterior cerebral artery through the internal carotid artery. The effect of PROG was assessed by determining water,sodium, potassium, and calcium contents in striatum of rats subjected to 2 h ischemia followed by 22 h reperfusion. RESULTS: The water,sodium,and calcium contents of middle cerebral artery occlusion(MCAO) striatum were obviously higher,the potassium content was obviously lower than those of non-MCAO striatum in I/R and DMSO groups,but there was no significant difference between these two groups.Compared with the result in I/R and DMSO groups , water, sodium and calcium contents significantly decreased, but potassium(P0.05). CONCLUSION: Treatment with PROG can significantly reduce the striatal injury of rats with cerebral ischmia-reperfusion.
