Responsiveness of the T-lymphocyte in peripheral blood from asthmatic patients to VIP
- VernacularTitle:哮喘患者外周血T淋巴细胞对VIP反应性的研究
- Author:
Changgui WU
;
Baoling MAO
;
Bi SUN
- Publication Type:Journal Article
- Keywords:
Asthma;
T-lymphocytes;
Hyperplasia;
Vasoactive intestinal peptide
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05). VIP, however, could inhibit the Con A-induced proliferation of T-cells from control subjects more significantly than that from asthmatics (P0.05). The cAMP level in T-cells, however, increased more significantly in the control group than that in the asthmatic group after the treatment of VIP or NaF (P0.05). CONCLUSION: Inhibition effect of VIP on Con A-induced proliferation of T-cells was less in asthmatics than in control subjects, which may be related to insufficiency of Gs ? coupled VIP receptor on T-lymphocytes in asthmatics.
