A study on the expression of sialyl Lewis X in colorectal carcinoma
- VernacularTitle:唾液酸化LewisX在大肠癌中的表达研究
- Author:
Peizhong SHANG
;
Huaping GU
;
Yinchen SUN
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Sialic acids;
Immunohistochemistry;
Microscopy, immunoelectron
- From:
Chinese Journal of General Surgery
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and distribution of sialyl Lewis X in colorectal carcinoma and its relationship with carcinogenesis, progression and metastatic proclivity.Methods Microwave LSAB immunohistochemical technique was used to detect the expression of sialyl Lewis X in colorectal carcinoma and in normal mucosa. Immunoelectromicroscopic localization of sialyl Lewis X labelled by colloidal gold was also observed.Results The positive rate of sialyl Lewis X expression in primary colorectal cancer was 92 2%(83/90), and 16 7%(5/30) in normal mucosa. The positive rate was 100% in patients with lymphatic nodes metastasis, compared with that of negative nodes of 82 1% ( P
