The effect of salvia miltiorrhiza on the expression of Bcl-2、Bax and hepatocyte apoptosis in hepatic preservation and reperfusion
- VernacularTitle:丹参对肝脏保存再灌注时Bcl-2、Bax表达和肝细胞凋亡的影响
- Author:
Haoliang ZHAO
;
Xiaoyong WU
;
Zhengzhong LI
- Publication Type:Journal Article
- Keywords:
Reperfusion injury;
Gene expression;
Cell death;
Salvia miltiorrhiza
- From:
Chinese Journal of General Surgery
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of salvia miltiorrhiza (SM) on the expression of Bcl 2?Bax and hepatocyte apoptosis in hepatic preservation and reperfusion in a murine model.Methods The model of the preservation reperfusion of isolated rat liver was established. Bcl 2?Bax expression of the liver tissue and hepatocyte apoptosis were studied respectively by flow cytometry and in situ terminal deoxynucleotidyl transferase mediated dUTP FITC nick end labeling (TUNEL) technique. Results In SM treated group levels of Bcl 2 expression was significantly increased ( P
