Pharmacokinetics of Xiaoer Reganning Injection in Rabbits
- VernacularTitle:小儿热感宁注射液在兔体内的药代动力学研究
- Author:
Xuemei HUANG
;
Mei LU
;
Hongping PAN
;
Shuhan JING
- Publication Type:Journal Article
- Keywords:
Xiaoer Reganning injection;
puerarin;
pharmacokinetics;
HPLC
- From:
China Pharmacy
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:The pharmacokinetics of Xiaoer Reganning injection was determined in rabbits METHODS:The concentrations of puerarin in Xiaoer Reganning injection in plasma were determined by HPLC The analytical column was No _va-pak C18 (4?m,150mm?3 9mm ID) The mobile phase consisted of methol-water(20∶80) The detecting wavelength was 250nm The 3p87 program was used to calculate the pharmacokinetic parameters RESULTS:The in vivo pharmacokinetic course of puerarin in Xiaoer Reganning injection could be described as an open two-compartment model Its main pharmacokinetic parameters were as follows:T1/2(?)=5 25min,T1/2(?)=36 04min,K10=0 042min,K12=0 063min,K21=0 093min,AUC=2 561 49?g/(ml?min),CL=4 6ml/(min?kg) CONCLUSION:This study will provide a scientific basis for clinical use of Xiaoer Reganning injection
