The Effects of N-acetylcysteine on Plasma Amino-acids in Animals With Fulminant Hepatic Failure
- VernacularTitle:N-乙酰半胱氨酸对暴发性肝功能衰竭动物血浆氨基酸的影响
- Author:
Pei WANG
;
Ximing WU
- Publication Type:Journal Article
- Keywords:
N-acetylcysteine;
fulminant hepatic failure;
plasma amino-acid
- From:
China Pharmacy
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the relationship between therapeutic effects of N-acetylcysteine(NAC) on animals with fulminant hepatic failure and contents of plasma amino-acids METHODS:Plasma amino-acids were analysed as their precolumn derivatives with O-phthol-dialdehyde by reversed-phase high-performance liquid chromatographic separation and fluorescence detection RESULTS:NAC could decrease the contents of plasma amino-acids,increase the ratio of BCAA/AAA and decrease the mortality of fulminant hepatic failure animals CONCLUSION:Therapeutic effects of NAC on animals with fulminant hepatic failure were related to its effect on the contents of plasma amino-acids
