Hyaluronan preserves the membrane transport properties in chronic peritoneal dialysis animal model of rats
- VernacularTitle:透明质酸在大鼠慢性腹膜透析模型中的作用
- Author:
Qunying GUO
;
Rengao YE
;
Tao WANG
;
Wenxin PENG
- Publication Type:Journal Article
- Keywords:
Hyaluronic acid;
Peritoneal dialysis;
Rats
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: We have shown that intraperitoneal (IP) addition of hyaluronan could increase peritoneal fluid removal by decreasing peritoneal fluid absorption rate. In this study, we investigated the impact of chronic use of hyaluronan on peritoneal membrane transport characteristics. METHODS: Twenty male SD rats received daily IP injection of 25 mL 4.25% glucose dialysis solution without (HP, n=8) or with 0.025% hyaluronan (HA, n=6) for one week, another six rats did not receive any peritoneal injection. Twenty-four hours after the last injection, a 4h dwell study using 25 mL 4.25% glucose dialysis solution with IP volume marker and frequent dialysate and blood samplings were performed in each rat. RESULTS:IPV was significantly higher in the HA group as compared to the HP group (ANOVA repeated measurement, P
