Effects of nitric oxide and endothelin on relaxation and contraction of isolated splanchnic vascular strips in cirrhotic rats
- VernacularTitle:一氧化氮和内皮素对肝硬化大鼠离体内脏血管条舒缩的影响
- Author:
Jinsheng YU
;
Kuohuan LIANG
;
Dean TIAN
;
Tiancai WANG
;
Wangxian TANG
;
Wenying ZHANG
;
Me LIU
- Publication Type:Journal Article
- Keywords:
Nitric oxide;
Endothelins;
Hypertension, portal;
Liver cirrhosis
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the different vasoactive effects of nitric oxide (NO) and endothelin (ET) on splanchnic arterial and venous vessels in cirrhotic rats. METHODS: Cirrhosis was induced in Wistar rats by subcutaneously administration of carbon tetrachloride. Maximal relaxation (Rmax) and contraction (Cmax) to NO and ET were determined in vitro using isolated vascular strips prepared from portal vein (PV) and mesenteric artery (MA) of both cirrhotic and normal rats, and EC50 was calculated for effects of NO and ET, respectively. RESULTS: Rmax of PV and MA to sodium nitroprusside (SNP) (releasing NO) were significantly higher in cirrhotic rats (n=8) than those in normal rats (n=7), and EC50 of NO were dramatically lower in cirrhotic rats than those in control (P
