Effect of chronic hypoxia on L-Arginine/nitric oxide pathway in rat pulmonary artery
- VernacularTitle:慢性低氧对大鼠肺血管L-精氨酸/一氧化氮途径的影响
- Author:
Jingjiong CHEN
;
Yongsheng GONG
;
Luzhen ZHEN
;
Zhongsun JIANG
;
Chaoshu TANG
;
Yongzhen PANG
- Publication Type:Journal Article
- Keywords:
Nitric oxide;
Anoxia;
Hypertension,pulmonary
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effect of chronic hypoxia on L-Arginine/NO pathway in rat pulmonary artery. METHODS: Changes in pulmonary artery L-Arginine(L-Arg) transport, nitric oxide synthase (NOS) activity, plasma nitrite level and L-Arg level in HPH rats were investigated. RESULTS: (1) The mean pulmonary arterial pressure (mPAP) and weight ratio of right ventricle to left ventricle and septum (RV/LV+S) of HPH group were higher than those in control group (P
