Relationship between expression of heme oxygenase-1 mRNA and pulmonary hypertention induced by hypoxic hypercapnia
- VernacularTitle:血红素氧合酶1基因表达与慢性低氧高二氧化碳性肺动脉高压的关系
- Author:
Xiaoying HUANG
;
Liangxing WANG
;
Shaoxian CHEN
;
Zhengjie XU
;
Qunji WANG
;
Xiaofan FAN
- Publication Type:Journal Article
- Keywords:
Carbon monoxide;
Heme oxygenase;
Anoxia;
Hypercapnia;
Hypertension,pulmonary;
Genes
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effect of chronic hypoxic hypercapnia on expression of heme oxygenase-1(HO-1). METHODS: Sprague-Dawley rats were randomly divided into three groups: control group(A),hypoxic hypercapnic group(B), hypoxic hypercapnia+hemin group(C). HO-1 and HO-1 mRNA were observed in pulmonary arterioles by the technique of immunohistochemistry and in situ hybridization. RESULTS: ① mPAP and weight ratio of right ventricle(RV) to left ventricle plus septum (LV+S) were significantly higher in rats of B group than those of A and C group (P0.05). ② Blood CO concentration was significantly higher in rats of B group than that of A group(P
