Effect of intestinal endotoxemia on hepatic energy metabolism in acute liver failure
- VernacularTitle:急性肝衰竭时肠源性内毒素血症对肝脏能量代谢的影响
- Author:
Dabin REN
;
Dewu HAN
;
Yuanchang ZHAO
- Publication Type:Journal Article
- Keywords:
Liver;
Endotoxins;
Energy metabolism;
Rats
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To study the effect of intestinal endotoxemia(IETM) on hepatic energy metabolism in acute liver failure. METHODS:Intoxication by thioacetamide (TAA) was used to establish rat model of acute liver injury.Ketone body(acetoacetate and ?-hydroxybutyrate) in arterial blood and ATP content of hepatocellular mitochondria were determined by using enzymatic fluorimetric micromethod.Colectomy was adopted in observing the changes in plasma endotoxin content and serum alanine aminotransferase (ALT) activity. RESULTS:In the TAA group,plasma endotoxin content and serum ALT activity were all significantly higher than those in the control group(P
