Study on in Vitro Percutaneous Permeability of Methylphenidate Cream
- VernacularTitle:哌甲酯乳膏体外透皮吸收试验研究
- Author:
Weijuan ZHAO
;
Jiaming BIAN
;
Mei ZHANG
;
Jun XUE
- Publication Type:Journal Article
- Keywords:
methylphenidate;
azone;
percutaneous absorption
- From:
China Pharmacy
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To study in vitro percutaneous permeability of methylphenidate cream. METHODS: Isolated rat skin was taken as permeable barrier. The influence of different concentrations of azone(0%, 2%. 5% ) in methylphenidate cream on drug permeation was observed. RESULTS: Steady-state percutaneous flow(J ) of methylphenidate cream with 2% and 5% azone increased 27. 80% and 49. 05%. respectively. CONCLUSION: Methylphenidate cream will be a safe. effective and conve- nient new preparation.
