Pathological Research of Cerebral Protection of Memantine in Neonatal Rat Models with Hypoxic-ischemia
- VernacularTitle:1-氨基-3,5甲基金刚烷盐酸对缺氧缺血损伤新生大鼠脑保护作用的病理研究
- Author:
Huijin CHEN
;
Zhongde ZHANG
;
Zehan ZHOU
- Publication Type:Journal Article
- Keywords:
Cerebral anoxia;
Cerebral ischemia;
Memantine
- From:
Chinese Journal of Perinatal Medicine
1998;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the cerebral protection of Memantine in neonatal rats with hypoxic ischemia. Methods Memantine was intraperitoneally injected at a dose of 20 mg/kg in neonatal rats of cerebral hypoxic ischemia (HI). Employing a quantized score system of cerebral pathology for hypoxic ischemia developed, the neuroprotective effect of Memantine was evaluated pathologically. Results There were significantly decreased scores in either PRE group (Memantine was given one hour before HI) or POST group (Memantine was given after HI immediately) comparing to HI group with higher score. Conclusion Memantine can improve cerebral hypoxic ischemic damage significantly, and be potentially valuable for the treatment of neonatal hypoxic ischemic brain damage.
