The Ototoxicity of Amikacin With Therapeutic Doses on Neonatal Guinea-pigs
- VernacularTitle:丁胺卡那霉素治疗剂量在新生豚鼠的耳毒性研究
- Author:
Hongmei XU
;
Shaoying WANG
- Publication Type:Journal Article
- Keywords:
Amikacin;
Ear;
Guinea pigs;
Toxicity tests
- From:
Chinese Journal of Perinatal Medicine
1998;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the possibility of ototoxicity of aminoglycosides on neonatal guinea pigs of different age groups (including premature) receiving amikacin with therapeutic doses. Methods Amikacin was injected intramuscularly with a dose of 65 mg/kg once a day for 14 days in neonatal, infant, and adult groups with 48 guinea pigs each, and 15 in premature group. 5~8 guinea pigs in each group were sacrificed for histological examination of cochlea with microscopy and scanning electron microscopy on the 3 rd, 5 th, 7 th, 10 th and 14 th day, as well the 28 th, 60 th day. There were 6 guinea pigs in each age group for control. Results Many stereocilia were lain down or disappeared as early as the 3 rd day and outer hair cells were absent on the 5 th day in either premature or neonatal group. The numbers of absent hair cells in neonatal group were more than those in infant and adult groups after the 7 th day ( P
