Relationship between methylenetetrahydrofolate reductase gene polymorphism and diabetic retinopathy
- VernacularTitle:甲基四氢叶酸还原酶基因多态性与糖尿病视网膜病变的关系
- Author:
Longqing WANG
;
Jiyi WANG
;
Yaoming XUE
- Publication Type:Journal Article
- Keywords:
Tetrahydrofolate dehydrogenase/metabolism;
Diabetic retinopathy/metabolism;
Polymorphism,restriction fragment length;
Polymerase chain reaction
- From:
Chinese Journal of Ocular Fundus Diseases
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To study the relationships between methylenetetrahydrofolate reductase(MTHFR) gene polymorphism and diabetic retinopathy (DR) in Chinese Han race. Methods With polymerase chain reaction and restriction fragment length polymorphism (PCR RFLP), MTHFR gene 677 T mutation (cytosine is replced by thymine in No.677 site) was detected in 85 health controls, 62 with DR and 117 without DR of type 2 diabetics comfrimed by ophthalmoscope. Results The frequency of MTHFR variant genotypes and alleles of DR in Chinese Han race.patients were signigicantly higher than those without retinopathy and healthy controls (P
