The effect of Evans blue on determining the breakdown of blood-retina barrier
- VernacularTitle:伊凡思蓝在测定血视网膜屏障破坏中的作用
- Author:
Qingwen XU
- Publication Type:Journal Article
- Keywords:
Evans blue/diagnostic use;
Blood retina barrier;
Endothelial growth factors/analysis;
Diabetes mellitus
- From:
Chinese Journal of Ocular Fundus Diseases
2001;0(03):-
- CountryChina
- Language:Chinese
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Abstract:
Objective To verify the effect of Evans blue dye on determining the retina blood vessel leakage. Methods Male Sprague Dawley rats were used in this study. The VEGF induced retinal blood vessel leakage was checked with Evans blue dye. Then the blood retina barrier breakdown of 1 week diabe tic animals was quantified with Evans blue. The dye was extracted from retina by formamide and the extraction was checked with spectrophotometer. Evans blue leakage was normalized against wet or dry retina weight. Results The retinal Evans blue content of eyes treated with VEGF was remarkably higher than that of the controls (n=17, P
