Role of coral artificial bone composite of human recombinant bone morphogenetic protein-2 in repairing alveolar bone
- VernacularTitle:重组人骨形成蛋白-2-珊瑚人工骨复合物在拔牙窝牙槽骨修复中的作用
- Author:
Wei LIN
;
Xiaolan LI
;
Weidong KONG
;
Guozhen DENG
;
Liji SHEN
- Publication Type:Journal Article
- Keywords:
Bone morphogenetic proteins;
Graft survival
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: This study was conducted to evaluate the bone repairing ability of coral artificial bone(CAB) composite of human recombinant bone morphogenetic protein-2(rhBMP-2-CAB) implanted into extraction sockets. METHODS: 12 adult dogs served as the experimental animals. Immediately after extraction of the upper second and third incisors, rhBMP-2-CAB and CAB were respectively implanted into each site of extraction sockets. The bone repairing ability of the two grafts was analyzed with histology, image analysis system and radionuclide bone imagining at 4th, 8th and 12th week, respectively. RESULTS: rhBMP-2-CAB were absorbed gradually after implanted into alveolar bone defect and were replaced completely by bone at 12 weeks. The ratio of new bone formation of rhBMP-2-CAB was significantly higher than that of CAB at different time( P
