Protective effects of diltiazem on liver, pancreas and small intestine in hemorrhagic-shock canine
- VernacularTitle:地尔硫对失血性休克犬肝、胰、小肠组织的保护作用(英文)
- Author:
Yuqin ZHANG
;
Yongming LIU
;
Jingpin OUYANG
- Publication Type:Journal Article
- Keywords:
Diltiazem;
Shock, hemorrhagic;
Free radicals;
Digestive system
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the protective effects of diltiazem (Dil) on liver, pancreas and small intestines in hemorrhagic-shock canines and its mechanism. METHODS: The canines were bled to a mean arterial pressure (MAP) of 5.33-6.67 kPa for 30 min to produce the model of shock. During the shock, the dogs received water-soluble calcium channel blocker Dil or normal saline. The MAP was kept at the level for 90 min, then the total blood which was bled previously was reperfused . They were observed for 240 min. RESULTS: Dil could significantly elevated MAP of the hemorrhagic-shock canines ( P
