Role of renin-angiotensin system in the kidney ischemic injury induced by renovascular hypertension
- VernacularTitle:肾内血管紧张素系统在高血压性肾损害中的作用
- Author:
Yi ZHOU
;
Hui OUYANG
- Publication Type:Journal Article
- Keywords:
Angiotensin II;
Receptors, angiotensin;
Ischemia;
Kidney
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the role of angiotensin II (Ang II)and Ang II receptor (Ang II R) in the ischemic injury of kidney.METHODS: The expression of renal Ang II type 1 receptor (AT 1R) gene in renovascular hypertensive rats was detected by reverse transcriptase-polymerase chain reaction (RT-PCR), and levels of Ang II in the kidney and plasma were examined by radioimmunoassay.RESULTS: The study showed that the contents of Ang II in plasma and renal tissue in experimental group were increased signifiantly ( P
