Microbiological Methodology for Detecting Plasma Doxycycline
- VernacularTitle:微生物法测定血浆中多西环素的方法学研究
- Author:
Guixiong ZENG
;
Qicai LONG
;
Min HUANG
- Publication Type:Journal Article
- Keywords:
microbiological method;
Staphylococcus aureus ATCC 26003;
Micrococcus luteus ATCC 28001;
bovine heart soup culture;
doxycycline
- From:
China Pharmacy
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To develop a microbiological method for determining plasma doxycyclineMETHODS:Plasma concentration of doxycycline was detected with Staphylococcus aureus ATCC 26003 and Micrococcus luteus ATCC 28001 strains in a variety of culture media and pHsRESULTS:Linear scope of doxycycline(016～100mg/L,r=09 985) could be achieved with using a microbiological method,which consisted of staphylococcus aureus and bovine heart soup culture medium at pH 50CONCLU_SION:This method can be used in study of pharmacokinetics and bioavailability of doxycycline
