Studies on Pharmacokinetics and Relative Bioavailability of Two Kinds of Cefaclor Capsule in Healthy Volunteers
- VernacularTitle:2种头孢克罗胶囊的人体药代动力学及相对生物利用度研究
- Author:
Chun DONG
- Publication Type:Journal Article
- Keywords:
cefaclor;
capsule;
pharmacokinetics;
bioavailability;
bioequivalence
- From:
China Pharmacy
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the pharmacokinetics and relative bioavailability of two kinds of cefaclor capsule in healthy volunteersMETHODS:Plasma cefaclor concentrations were measured with HPLC methodEach subject was administered with a single oral dose of domestic or imported cefaclor capsule(500mg)in a randomized crossover studyRESULTS:Plasma concentration-time curves of domestic and imported cefaclor capsules fitted to a one-compartment open model with a first order absorptionThe peak plasma levels(Cmax)averaged(1324?242)and (1329?314)?g/ml,times to reach the peak level(Tmax)were (058?0192)and(055?010)h,the elimination half lives(T1/2)were (042?009)and(041?009)h,the areas under the plasma concentration-time curve(AUC0～T)were (1581?153)and(1568?197)h/(?g?ml)respectivelyCONCLUSION:The results of statistical analysis showed that the two formulations were bioequivalentThe relative bioavailability of domestic capsule was(10084?778)%
