Effect Angiotensin Ⅱ type 1 Receptor(AT_1R) Antagonist on Neointima Formation after Vascular Balloon Injury
- VernacularTitle:血管紧张素Ⅱ-1型受体拮抗剂对血管球囊损伤后内膜形成的影响
- Author:
Lizhi DENG
;
Xinhong WAN
- Publication Type:Journal Article
- Keywords:
Angiotensin receptor;
Antagonist;
Vascular endothelia;
Injury
- From:
Journal of Chinese Physician
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of angiotensin Ⅱ type 1 receptor(AT 1R) antagonist,TCV-116,and angiotensin-converting enzyme inhibitory(ACEI),Delapril on neointimal formation after carotid balloon injury in rats. Method TCV-116 and Delapril were administered p.o for 3 weeks(1 weeks before and 2 weeks after carotid balloon injury) in SHR.Neointimal formation of carotid artery was examined.Results Compared with the control group,neointima/media area ratio was significantly reduced(48 3% and 45 5% respectivity,P
