The alteration of urotensin-II receptors in rat aorta after balloon angioplasty injury
- VernacularTitle:大鼠主动脉球囊成形术后尾加压素II受体的变化
- Author:
Chunfang XIA
;
Shaoping XU
;
Yonggang ZHANG
;
Jun YANG
;
Yong HUO
;
Yongzheng PANG
;
Chaosh TANG
- Publication Type:Journal Article
- Keywords:
Urotensins;
Receptor, endogenous substances;
Angioplasty, balloon;
Rats;
Aorta
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the alteration of urotensin II (UII) receptors and contractile response to UII in rat aorta after balloon angioplasty injury. METHODS: The plasma membrane isolated from balloon injured aorta was used to study the binding of [ 125 I]-UII to the membrane and the contractile potency of UII on rat aorta was assayed. RESULTS: In contrast to the normal aorta, the contractile potency to UII enhanced in balloon injury artery and the calculated maximal number of specific binding sites (Bmax) was increased about 44% and 36% respectively in rat artery after balloon injury 3 and 21 days ( P
