Effects of glycine/polymyxine B mixture on endotoxin-induced acute phase response in rabbits
- VernacularTitle:甘氨酸/多粘菌素B合剂对内毒素诱导的急性期反应的影响
- Author:
Renbin QI
;
Daxiang LU
;
Huadong WANG
;
Jun DONG
;
Yanping WANG
;
Yongmei FU
;
Haozhuang YANG
;
Suimei ZHANG
;
Chujie LI
- Publication Type:Journal Article
- Keywords:
Glycine;
Polymyxin B;
Endotoxins
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore effects of glycine and polymyxin B mixture (Gly/PMB) on endotoxin-induced acute phase response in vivo . METHODS: Model of acute phase response was reconstructed by endotoxin (ET) in rabbits. Specimens of blood were collected at 1 hour after the highest body temperature. Leukocyte count, serum C-reactive protein and trace element were also detected. RESULTS: Pretreatment of half-dose Gly/PMB significantly inhibited acute phase response induced by ET ( P 0.05). CONCLUSION: These results suggested that glycine enhanced the inhibitory effect of polymyxin B on ET-induced acute phase response. The advantage of glycine and polymyxin B mixture was decreasing dosage and side effects of polymyxin B. [
