Effects of hippocampus NE or Ach system disfunction on P3-like potential in rats
- VernacularTitle:海马去甲肾上腺素能及乙酰胆碱能系统损伤对大鼠类P3的影响
- Author:
Liming SUN
;
Yuechun WANG
;
Zidong WANG
;
Lijun WANG
;
Xinghui LIN
- Publication Type:Journal Article
- Keywords:
Hippocampus;
Dopamine;
Acetylcholine;
Norepinephrine
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the change in cognitive function in derogative state of different neurotransmitter by mensurating P300 amplitude and latency. METHODS: Acetylcholine (ACh) system was disfunctioned by severing fimbrial-fornix(FF) transaction and Norepinephrine (NE) system impaired by injection of 6-hydroxysopamine into the bilateral dorsal noradrenergic bundle in DG. Then Y-type maze test and elicitation of P3-like latency were carried out separately before and after the all models were built. RESULTS: In both experimental groups, P3-like latency was prolonged significantly compared with the control and had positive correlation with indices of Y-maze test(EN,TRT). CONCLUSION: ACh and NE are important in the production and conformity of P300.
