Synergic antitumor effect of verapamil and tumor necrosis factor alpha
- VernacularTitle:异搏定和肿瘤坏死因子?协同抗肿瘤作用的实验研究
- Author:
Hong ZHANG
;
Shuxin HOU
;
Wanding LI
;
Jiny LI
- Publication Type:Journal Article
- Keywords:
Verapamil;
Tumor necrosis factor;
Hepatoma
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the synergic antitumor effect of verapamil (VPL) and tumor necrosis factor alpha (TNF?). METHODS: In the presence of verapamil or verapami plus tumor necrosis factor, the proliferation, the expressions of c-myc and PCNA, the mean vessel density(MVD)of human hepatoma cell line(HepG 2) were studied in vivo and in vitro. RESULTS: It was demonstrated that the growth of HepG 2 was inhibited remarkably, under the presence of verapamil and TNF? simutaneously, the expressions of c-myc , PCNA and the MVD were also decreased. CONCLUSION: The calcium channel blocker can inhibit the proliferation of tumor and has a remarkable synergy with TNF?. [
