Effect of Fu-Sheng powder on NPY and its mRNA in brain of rats with hyperlipidemia after cerebral ischemia and reperfusion
- VernacularTitle:复圣散对高脂大鼠脑缺血再灌后脑内NPY含量及其mRNA表达的影响
- Author:
Yan LEI
;
Qifu HUANG
;
Yongya WANG
- Publication Type:Journal Article
- Keywords:
Powders;
Brain;
Ischemia;
Reperfusion injury;
Neuropeptide Y;
RNA,messenger;
Rats
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the changes in neuropeptide Y(NPY) and the effect of Fu-Sheng powder(FSP) on NPY in the rat brain in a steady cerebral ischemia and reperfusion(I/R) model. METHODS: The models of rat brain injury were established by repeated cerebral I/R in rats with hyperlipidemia. Radioimmunoassay was performed to determine the level of NPY, while NPY mRNA expression was observed by in situ hybridization. RESULTS: After 1 day of I/R, compared with control group, the content of NPY in the model animals were significantly increased by 51.86% ( P
