Increased expression of extracellular signal-regulated kinase in human gastric cancer
- VernacularTitle:细胞外信号调节激酶在胃癌中的过表达与胃癌的恶性潜能相关
- Author:
Bin LIANG
;
Shan WANG
;
Xueguang ZHU
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Extracellular signal regulated kinases;
Protein hybridization;
Immunohistochemistry
- From:
Chinese Journal of General Surgery
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of extracellular signal regulated kinase(ERK) in human gastric cancer and evaluate the relationship between ERKs protein level and clinicopathological parameters. Method Western blot was used to measure the activity and expression of ERK 1 and ERK 2 proteins and immunohistochemistry was used for localization in 42 gastric cancer patients.Results ERK 1 and ERK 2 protein levels increased in gastric cancer tissues in comparison to normal tissues ( P 0 05). Expression of ERK 1 and ERK 2 showed a positive linear correlation (r=0 550, P
