A study on the expressions of p21~(WAF1) and p53 protein in cholangiocarcinoma
- VernacularTitle:p21~(WAF1)和p53基因在胆管癌组织中的表达研究
- Author:
Kunlun LUO
;
Zhenping HE
;
Kuansheng MA
- Publication Type:Journal Article
- Keywords:
Cholangiocarcinoma;
Oncogene proteins;
Immunohistochemistry
- From:
Chinese Journal of General Surgery
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objection To study the p21 WAF1 and p53 protein expression in patients with cholangiocarcinoma and its relation to the pathologic grading and metastasis of the tumor.[WT5”HZ] Methods Using immunohistochemical method, we examined p21 WAF1 and p53 protein expression in 48 cases of cholangiocarcinoma and 8 cases of biliary duct tissue with chronic inflammation.[WT5”HZ] Results The expression of p21 WAF1 and p53 was positive in 25% and 54% respectively of the cases with cholangiocarcinoma, and 88% and 0% respectively of the cases in normal bile duct tissue with chronic inflammation (all P
