Effects of Serum of Mice Treated With Ruixiang Langdu(Stellera chamaejasme L.) abstract on Proliferation and Clonal Formation of K562 Cells
- VernacularTitle:瑞香狼毒水提物小鼠的药物血清对K562细胞增殖的影响
- Author:
Hua XIE
;
Zhengping JIA
;
Liting XU
;
Rong WANG
;
Junjie FAN
- Publication Type:Journal Article
- Keywords:
stellera chamaejasme L.;
seropharmacology;
K562 cell;
clone cell
- From:
China Pharmacy
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the antitumor mechanism of Ruixiang Langdu(Stellera chamaejasme L ) abstracts(SCA) METHODS:SCA-contained serum was derived from mice pre-administrated with different oral dosages of SCA and at different times after administration The effects of the serum on the proliferation of K562 leukemic cells were observed with MTT assay and clone formation RESULTS:After mixing with the SCA-contained serum derived at 1,2,4,8h after giving SCA(3,6 and 12g/kg),the rates of MTT transformation and clone formation of K562 cells were decreased significantly The SCA-contained serum 12 h after giving drug was more effective than others CONCLUSION:The SCA-contained serum inhibited the proliferation of tumor cells,which may be one of its important antitumor mechanism
