Study on Dissolution Test Methods for Diclofenac Sodium Suppository
- VernacularTitle:双氯芬酸钠栓溶出度测定方法的研究
- Author:
Chuhong XU
;
Yongning LU
;
Hu WANG
- Publication Type:Journal Article
- Keywords:
diclofenac sodium suppository;
dissolution;
first derivative spectrophotometry
- From:
China Pharmacy
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish a good method for determining the dissolution rates of diclofenac sodium suppository METHODS:The dissolution method Ⅰ and Ⅱ of ChP(2000) were compared,the first derivative spectrophotometry was used and the parameters(T50,Td,m) obtained from these samples were brought for correlation analysis RESULTS:The dissolution rate of diclofenac sodium suppository from the dissolution method Ⅰ and Ⅱ were remarkably different,and the dissolution method Ⅱ was better than Ⅰ CONCLUSION:The method established by this study is suitable for the quality control of diclofenac sodium suppository,and the percentage of dissolution of diclofenac sodium suppository in 45min more than 80% is the standard of quality control
